The thought of aging scares us all. Thanks to revolutionary medical science, which has introduced us to novel anti-aging products to limit the effect of aging on our body and mind. Metformin is amongst the most popular and effective anti-aging products.
This article encapsulates the mechanism of the Metformin anti-aging process, its potential in comparison with other anti-aging products, and highlights its anti-aging properties with recent evidence.
Metformin; a weapon against aging
Aging is a gradual process of deterioration of the physiological functions controlling fertility and survival. With increasing age, it triggers the scariest diseases like cancer, cardiac malfunction, osteoporosis, cognitive decline, type 2 diabetes, Alzheimer’s disease, dementia, cataracts, etc.
This process can be slowed down if not fully hindered. The extensive research on this critical topic has led to the manufacture of Metformin. These pills are manufactured by using the guanidine derivatives present in the Galegaofficinalis plant. It is a biguanide compound, which slows down the aging phenomenon and its related diseases.
Mode of action of Metformin
Metformin works by modifying the conserved processes involved in aging at the micro-level. The basic mechanism which Metformin uses is to suppress the formation of reactive oxygen species (ROS), ultimately lowering the oxidative DNA deterioration. Its molecular basis lies in its ability to hinder the mitochondrial complex 1 in the ETC (electron transport chain).
Metformin inhibits the hepatic gluconeogenesis through the process of AMP-activated protein kinase (AMPK) activation, which is a cornerstone of energy regulation. Metformin uses various other methods to inhibit hepatic gluconeogenesis like downregulation of genes that encode the glucose-6-phosphate, gluconeogenic enzymes, and phosphoenolpyruvate carboxylase (PEPCK).
However, this also depends on the AMPK activation ability of Metformin. AMPK activation lowers insulin levels, inhibits protein kinase mTOR (involved in aging and its related disease), and IGF-I signaling.
Moreover, Metformin elevates the insulin-independent phosphorylation of both the receptors and receptor substrates and translocate GLUT4 (glucose transporters) to the plasma membrane to elevate glucose homeostasis. It can also increase insulin sensitivity and glycolysis.
Metformin also has the ability to control age-related phenomena such as autophagy, cellular senescence, inflammation, protein glycation, fatty liver, etc.
Why prioritize Metformin over other anti-aging products?
The efficiency and reliability of Metformin have made it one of the most in-demand antidiabetic drug in the world. Its major benefit is that it doesn’t need liver or kidney metabolism as it is excreted intact in urine. Its absorption rate in systemic circulation and other tissues is approximately 50-60%. It prevents long term side effects, unlike other pills.
Experimental evidence of anti-aging properties
Several experiments on model organisms revealed that Metformin extended the lifespan of C. elegans as well as in outbred female mice by 40%. It extended the lifespan by 8% by halting the carcinoma in the breast cancer model and increased the lifespan by 20% in Huntington’s disease.
Age-related diseases have also been targeted in humans to test the properties of Metformin. A clinical trial of Diabetes Prevention program conducted in the U.S revealed that Metformin suppressed the rate of T2DM by 31% than placebo over an average follow-up of 3 years, decreased CVD, and subclinical cardiac diseases in males. In a study at the Singapore Longitudinal Aging Study, it was also revealed that this drug decreases the cognitive impairment risk by 51%.
The wide-ranging studies have proved Metformin as an effective weapon against aging. So if you are getting troubled by it, don’t waste more time and buy Metformin anti aging online or from your primary care physician. Learn more about it at AgelessRx.com.